Anti-fibrotic effect of human amniotic fluid stem cells in biliary epithelial-mesenchymal transition of liver ductal organoid
TGF-β1 is a potent cytokine that induces biliary EMT. hAFSCs significantly mitigated TGF-β1-induced biliary EMT in liver ductal organoids. The beneficial effect of hAFSCs administration is associated with the downregulation of the Wnt signaling pathway. This study indicates that hAFSCs can prevent the progression of liver fibrosis in BA.
Authors
- Dorothy Lee (ORCID: https://orcid.org/0000-0001-7736-4839)
- Kanokrat Thaiwatcharamas (ORCID: https://orcid.org/0000-0001-7769-6884)
- Dolrudee Aroonsaeng
- Felicia Balsamo
- Poramate Klanrit (ORCID: https://orcid.org/0000-0003-0209-3901)
- Patchareeporn Tanming
- Sinobol Chusilp (ORCID: https://orcid.org/0000-0001-6473-0385)
- Agostino Pierro (ORCID: https://orcid.org/0000-0002-6742-6570)
- Bo Li
- Carol Lee (ORCID: https://orcid.org/0000-0003-1865-1541)
- Paisarn Vejchapipat (ORCID: https://orcid.org/0000-0002-4388-6900)
Institutions
- Chulalongkorn University (TH)
- Khon Kaen University (TH)
- Hospital for Sick Children (CA)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1093/stcltm/szaf052
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hospital for Sick Children
- Canadian Institutes of Health Research