Association of energy expenditure with body composition and nutritional intake in male patients with esophageal and head and neck cancer

Objective;In order to maintain a patient's adequate nutritional status, it is important to accurately assess energy expenditure and to provide nutritional administration commensurate with that expenditure. In this study, we have assessed the resting energy expenditures (REE) in patients with esophageal and head and neck cancer, and association between REE, metabolites, nutritional intake, and body composition. Methods;Patients included in the study had to be diagnosed with esophageal and head and neck cancer, and hospitalized and receiving chemotherapy. REE was measured using indirect calorimetry with a mask and calculated using 3 different equations. Result;Patients with esophageal and head and neck cancer (67.1±8.5 years old, n=52, all patients were male) were enrolled. The average of REE measured by indirect calorimetry were 22.1kcal/kg/day. REE was positively correlated with muscle mass, body cell mass, and lean body mass. REE was higher in group with oral intake of more than 72%. Blood levels of lactate, pyruvate, and amino acids were higher in cancer patients with esophageal and head and neck cancer compared to healthy subjects. Conclusion:REE measured by indirect calorimetry correlated with the estimated BEE. There was an association between energy expenditure and muscle mass and nutritional intake. J. Med. Invest. 72 : 252-259, August, 2025.