Elevated LECT2 and PEDF in Pediatric MAFLD: Diagnostic Performance and Metabolic Correlations
LECT2 and PEDF are elevated in pediatric MAFLD and correlate with metabolic dysfunction. While their combination effectively distinguishes MAFLD from healthy controls, it shows moderate efficacy in differentiating MAFLD from simple obesity. Nevertheless, the LECT2/PEDF panel represents a promising risk-stratification tool to identify high-risk obese children for further diagnostic evaluation.
Authors
- Tuo Guo (ORCID: https://orcid.org/0000-0001-5679-8179)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-7455-0492)
- Hongbing Ni
- Wanqin Yang (ORCID: https://orcid.org/0000-0001-9626-3451)
- Lanshu Yang
- Baolan Sun
- Meiling Deng
Institutions
- Dalian Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Zhongda Hospital Southeast University (CN)
- Maternal and Child Health Hospital of Sichuan Province (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dmso.s555108
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00