The combination of CD8 and TIM3 expression predicts survival outcomes in hepatocellular carcinoma
The combination of CD8 and TIM3 expression which indicates T cell exhaustion was useful biomarker for predicting HCC prognosis than PD-1/PD-L1, suggesting that TIM3 may be a future target for immune checkpoint inhibition. J. Med. Invest. 72 : 354-360, August, 2025.
Authors
- Shinichiro Yamada (ORCID: https://orcid.org/0000-0003-3847-751X)
- Masaaki Nishi (ORCID: https://orcid.org/0000-0003-3845-457X)
- Yu Saito (ORCID: https://orcid.org/0000-0001-6349-1669)
- Tetsuya Ikemoto (ORCID: https://orcid.org/0000-0001-9800-1359)
- Mitsuo Shimada (ORCID: https://orcid.org/0000-0003-1255-4783)
- Takayuki Noma
- Hiroki Teraoku (ORCID: https://orcid.org/0000-0001-5730-9808)
- Yuji Morine
- Yuma Wada
Institutions
- Tokushima University (JP)
Publication Details
- Journal
- The Journal of Medical Investigation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2152/jmi.72.354
- Citations
- 2
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.94