Investigation of Platelet-Related Parameters and BMI in Children with Cyanotic and Non-Cyanotic Congenital Heart Disease

Background: Considering the role platelets play in hemostasis and coagulation, in the present study, we have examined plateletrelated parameters and BMI in children with cyanotic and non-cyanotic CHD. Methods: Fifty children with cyanotic and non-cyanotic CHD were investigated in this case-control study. Platelet-related parameters and other hematologic factors, weight, and BMI were evaluated. Results: The findings indicated a notable disparity in hemoglobin levels between cyanotic and non-cyanotic cases, with respective mean values of 14.44±2.64 and 12.66±0.77 (P=0.002). Also, the HCT was significantly higher in cyanotic CHD cases than in non-cyanotic cases (P=0.002). The regression analysis revealed that cyanotic children had 0.41 times lower odds of having higher weights compared to non-cyanotic children. The mean Hb and HCT in cyanotic children were 1.77 and 7.48 units higher than in non-cyanotic children, and the difference was statistically significant (P=0.002). The mean PDW in cyanotic children was 0.44 units lower than in non-cyanotic children, and the difference was statistically significant (P=0.009), and the mean PLT in cyanotic children was 117.687 units lower than in non-cyanotic children, which was not statistically significant (P=0.165). Conclusion: Based on the present findings, the platelet indices, specifically PDW and PLT, showed a strong inverse correlation with hematocrit levels, indicating that elevated hematocrit directly affects blood clotting in CCHD. Also, the results showed that the likelihood of elevated weight was lower in cyanotic children compared to non-cyanotic children.