Synchronous Primary Small Bowel Melanomas: A Case Report and Literature Review

Background: Malignant melanoma (MM) is an epithelial malignancy originating from melanocytes. Approximately 1%–3% of all gastrointestinal cancers are MM. The majority of these malignancies are metastases or secondary tumors. Case Report: A 52-year-old male was admitted to our hospital due to abdominal pain, nausea, loss of appetite, weight loss, and chronic constipation. An abdominal CT scan showed a mass of 76×173 mm in the left colon. During surgery, two distinct solid masses were seen in the jejunum, 25 cm and 10 cm in diameter, located about 30 cm and 50 cm after the Treitz ligament, respectively. A segmental enterectomy was performed. Pathology examination of the resected tumor identified MM. Discussion: Primary intestinal melanomas require follow-up due to their possibility of recurrence, invasive course, and poor prognosis. Conclusion: Early identification and resection surgery can improve quality of life and prolong the symptom-free survival time of MM.