Tumor mutational burden modulates the prognostic effect of RAS mutations in metastatic colon cancer: mechanistic insights and genotype-phenotype correlations
This study demonstrates a prognostic interaction between RAS mutations and TMB in mCC, identifying the RAS-mutant/TMB-low subgroup as having the poorest outcomes. Integrative bioinformatic analyses suggest distinct biological mechanisms underlying these differences. These findings support the development of tailored therapeutic and monitoring strategies for specific molecular subgroups.
Authors
- Rossella Sperlongano
- Carmine Picone (ORCID: https://orcid.org/0000-0002-5344-0056)
- Francesco Sabbatino (ORCID: https://orcid.org/0000-0001-6431-8278)
- Luisa Circelli
- Raffaella Ruggiero
- Anna Ceccarelli
- Antonio Barone (ORCID: https://orcid.org/0000-0003-1226-7565)
- Monica Ianniello
- Antonio Fico
- Mariachiara Santorsola
- Giuliana Ciappina (ORCID: https://orcid.org/0000-0003-0813-3126)
- Roberto Sirica (ORCID: https://orcid.org/0000-0002-3923-4889)
- Massimiliano Berretta (ORCID: https://orcid.org/0000-0002-9837-9148)
- Alessandro Ottaiano (ORCID: https://orcid.org/0000-0002-2901-3855)
- Michele Caraglia (ORCID: https://orcid.org/0000-0003-2408-6091)
- Nadia Petrillo (ORCID: https://orcid.org/0009-0008-5131-9528)
- Marco Bocchetti (ORCID: https://orcid.org/0000-0002-2143-6669)
- Alessia Maria Cossu
- Giovanni Savarese (ORCID: https://orcid.org/0009-0004-5274-3989)
- Enrica Toscano (ORCID: https://orcid.org/0009-0003-2362-764X)
- Francesco Caraglia (ORCID: https://orcid.org/0009-0000-1853-9897)
Institutions
- University of Messina (IT)
- University of Salerno (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Regione Campania (IT)
- Agostino Gemelli University Polyclinic (IT)
- Biogem (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Link Campus University (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12967-025-07273-w
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05