Prognostic evaluation and experimental validation of cuproptosis-related hub genes identified through weighted gene co-expression network analysis in uveal melanoma
Compared to several previous studies, we have extended the search for CRGs very rigorously in order to increase the value of cuproptosis in the prognosis and treatment of UVM. This whole transcriptome analysis elucidates the crucial role of cuproptosis-related molecular subtypes in the prognosis of UVM, highlights its association with the TME, and provides a scientific basis for clinical drug decisions.
Authors
- Guangqin Zhang (ORCID: https://orcid.org/0000-0002-0282-3807)
- Shaoxiang Wang (ORCID: https://orcid.org/0000-0001-7653-4883)
- Yitong Guo (ORCID: https://orcid.org/0000-0001-6104-2341)
- Boqing Zhang (ORCID: https://orcid.org/0000-0002-1507-6556)
- Nan Li (ORCID: https://orcid.org/0000-0002-7529-0781)
- Mingwei Li
- Siying Chen (ORCID: https://orcid.org/0000-0002-0111-3889)
- Chao Sun (ORCID: https://orcid.org/0000-0002-2910-0481)
- Qiuling Chen (ORCID: https://orcid.org/0000-0003-0565-8082)
- Chaowei Zhu (ORCID: https://orcid.org/0009-0007-0314-0649)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-8997-9256)
- Boning Zeng
Institutions
- China Pharmaceutical University (CN)
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- Shantou University (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- Key Laboratory of Guangdong Province (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Luohu People's Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12935-025-03978-6
- Citations
- 1
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71