Isoproterenol infusion enhances composition and function of G-CSF mobilized allogeneic peripheral blood hematopoietic cell grafts
ISO infusion post-G-CSF mobilization favorably enhances graft composition, mitigates GvHD, prolongs survival, and augments GvL effects. Our findings suggest that acute systemic beta-adrenergic receptor activation could be a valuable strategy to enhance outcomes in alloHCT.
Authors
- Preetesh L. Mylabathula (ORCID: https://orcid.org/0000-0002-8428-0251)
- Tiffany M. Zúñiga (ORCID: https://orcid.org/0000-0002-8511-479X)
- Kyle A. Smith (ORCID: https://orcid.org/0000-0002-4585-4240)
- Forrest L. Baker (ORCID: https://orcid.org/0000-0001-5338-7905)
- Emmanuel Katsanis (ORCID: https://orcid.org/0000-0003-1466-6965)
- Michael D. Seckeler (ORCID: https://orcid.org/0000-0001-9013-5723)
- Grace M. Niemiro (ORCID: https://orcid.org/0000-0002-2735-6272)
- Nicole M. De La Peña (ORCID: https://orcid.org/0000-0002-1302-6299)
- Helena Batatinha (ORCID: https://orcid.org/0000-0002-3410-5973)
- Douglass M. Diak
- Timothy M. Kistner
- Richard J. Simpson
- G. P. Hoskin
Institutions
- University of Arizona (US)
- University of Arizona Cancer Center
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13287-025-04725-4
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Arizona Cancer Center
- University of Arizona
- National Institutes of Health