BMP-2 gene-modified mesenchymal stem cells enhance tendon–bone healing in ACL reconstruction: a rabbit micro-CT and biomechanical study
BMP-2 gene-modified MSCs synergistically accelerate tendon-bone osseointegration, providing a theoretical foundation for biological augmentation in ACL reconstruction. This strategy may reduce postoperative graft failure risks. Future studies should validate clinical translation through long-term monitoring and mechanistic investigations.
Authors
- Husen Wang
- Ying Zeng (ORCID: https://orcid.org/0000-0003-2795-4616)
- Shu Li (ORCID: https://orcid.org/0000-0001-8063-6639)
- Bin Tang (ORCID: https://orcid.org/0000-0002-5194-6336)
- Hui Zheng (ORCID: https://orcid.org/0000-0002-1975-3307)
- Nacke Daoerji
Institutions
- Xinjiang Medical University (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- BMC Surgery
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12893-025-03277-x
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Medical University