Ustekinumab enhances intestinal stenosis resolution by modulating fibrotic pathways in Crohn’s disease: a retrospective single-center study with translational analysis
This study suggests that inhibition of the IL-22/TGF-β pathway by anti-IL-23 treatment with UST may reduce myofibroblasts and improve small intestinal fibrous stenosis in patients with CD.
Authors
- Masaki Ominami (ORCID: https://orcid.org/0000-0002-9692-0420)
- Yuji Nadatani (ORCID: https://orcid.org/0000-0001-7081-8746)
- Noriko Kamata
- Shusei Fukunaga (ORCID: https://orcid.org/0000-0002-9336-8271)
- Rieko Nakata (ORCID: https://orcid.org/0000-0001-9977-7239)
- Kiyoshi Maeda
- Hirotsugu Maruyama (ORCID: https://orcid.org/0000-0002-8728-8101)
- Koji Otani (ORCID: https://orcid.org/0000-0001-9075-6415)
- Shuhei Hosomi (ORCID: https://orcid.org/0000-0002-8808-5672)
- Yumie Kobayashi (ORCID: https://orcid.org/0000-0002-5747-6697)
- Fumio Tanaka (ORCID: https://orcid.org/0000-0002-9186-1249)
- Yasuhiro Fujiwara (ORCID: https://orcid.org/0000-0002-1225-1785)
- Yu Nishida (ORCID: https://orcid.org/0000-0003-3369-5059)
- Tatsunari Fukuoka
Institutions
- Osaka City University (JP)
- Osaka City General Hospital (JP)
- Osaka City University Hospital (JP)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12876-025-04386-w
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82