Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation
In summary, AA mitigates immunosenescence and improves cognitive function by targeting MYH9 to regulate CD8⁺ T cell differentiation and function. These findings establish a mechanistic basis for AA as a potential therapeutic agent against age-related immune and cognitive decline.
Authors
- Nan Wang (ORCID: https://orcid.org/0000-0003-2442-234X)
- Liuling Guo
- Jian‐Kang Zhu (ORCID: https://orcid.org/0000-0001-5134-731X)
- Shengyu Feng (ORCID: https://orcid.org/0000-0002-3189-4911)
- Hailiang Liu (ORCID: https://orcid.org/0000-0002-5521-3746)
- Tingting Su (ORCID: https://orcid.org/0000-0002-7091-8189)
- Shanshan Yang (ORCID: https://orcid.org/0009-0003-6203-8653)
- Hao Wang (ORCID: https://orcid.org/0000-0001-8428-9494)
- Meili Zhao (ORCID: https://orcid.org/0000-0001-5013-4259)
- Fengjiao Huo
- Taotao Mi
- Shuyao Lv
Institutions
- Shihezi University (CN)
- Tongji University (CN)
- Southern University of Science and Technology (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12979-025-00538-4
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Tongji University
- ShanghaiTech University
- Fundamental Research Funds for the Central Universities