Whole-exome sequencing of kidney transplant recipients and donors: insights into end-stage renal disease and post-transplant genetic risk
This study provides one of the first applications of WES in a Central Asian kidney transplant population. Findings highlight the prevalence of monogenic and comorbid risk variants in both recipients and donors and support the use of genomic screening for improving pre- and post-transplant care. The identification of immune-related SNPs and extra-renal findings further underscores the utility of WES for personalized transplant management. Integration of genomics into transplant workflows may help address the ongoing gap between clinical need and transplant outcomes, particularly in low-resource settings.
Authors
- Aliya Sailybayeva (ORCID: https://orcid.org/0000-0002-1489-3837)
- Mirgul Bayanova (ORCID: https://orcid.org/0000-0002-6167-5357)
- Sholpan Altynova (ORCID: https://orcid.org/0009-0000-5592-0400)
- Yuriy Pya (ORCID: https://orcid.org/0000-0001-7249-0510)
- Ardak Ainakulov (ORCID: https://orcid.org/0000-0002-5145-3398)
- Lyazzat Nazarova (ORCID: https://orcid.org/0000-0002-3325-5240)
- Gani Kuttymuratov (ORCID: https://orcid.org/0000-0003-4642-1452)
- Saltanat Rakhimzhanova (ORCID: https://orcid.org/0009-0005-9694-5491)
- Saitkarim Abdugafarov (ORCID: https://orcid.org/0000-0002-8393-9966)
- Aidos Bolatov (ORCID: https://orcid.org/0000-0002-5390-4623)
- Mels Assykbayev (ORCID: https://orcid.org/0000-0003-2386-0997)
- Aida Zhenissova (ORCID: https://orcid.org/0009-0008-6246-7075)
- Aizhan Abdikadirova (ORCID: https://orcid.org/0000-0002-1951-2837)
- Dias Malik (ORCID: https://orcid.org/0009-0008-3542-1960)
- Malika Sapargaliyeva (ORCID: https://orcid.org/0000-0002-0172-353X)
- Deniza Suleimenova (ORCID: https://orcid.org/0009-0001-7423-1392)
Institutions
- Shenzhen University (CN)
- National Center for Biotechnology (KZ)
- Astana Medical University (KZ)
- National Research Center for Maternal and Child Health (KZ)
- Nazarbayev University (KZ)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12882-025-04553-x
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00