Spatial Characteristics of Intraductal Carcinoma of the Prostate
Our results support a relatedness between invasive PCa and IDC-P, and show increased expression of markers related to PCa aggressiveness in the intraductal component. The spatial heterogeneity within IDC-P suggests a higher degree of hypoxia in the center of the lesion. Increased PD-L1 expression and loss of expression of some MMR genes in IDC-P could lead to increased sensitivity to immunomodulatory treatments.
Authors
- F. Bruyère (ORCID: https://orcid.org/0000-0002-9281-9421)
- R Dupuis
- Gaëlle Fromont (ORCID: https://orcid.org/0000-0002-7730-2264)
- Nathanael Fort
- Coralie Mousset
Institutions
- Université de Tours (FR)
- Université d'Orléans (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Hôpital Bretonneau (FR)
- Centre hospitalier universitaire d'Orléans (FR)
Publication Details
- Journal
- The Prostate
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1002/pros.70091
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00