Recombinant Irisin Therapy Alters Brain Transcriptome and Protects Against Ischemic Damage in Middle-Aged Rats
Post-transient middle cerebral artery occlusionirisin therapy modulates the transcriptome, enhancing motor and cognitive function while protecting against ischemic brain damage in middle-aged female rats.
Authors
- W. Dalton Dietrich (ORCID: https://orcid.org/0000-0002-8732-4942)
- Weizhao Zhao (ORCID: https://orcid.org/0000-0002-9890-5785)
- Ami P. Raval (ORCID: https://orcid.org/0000-0003-1757-9947)
- Danuta Szczesna‐Cordary (ORCID: https://orcid.org/0000-0002-8441-0722)
- Shahil H. Patel (ORCID: https://orcid.org/0009-0001-3423-7503)
- Zhexuan Zhang (ORCID: https://orcid.org/0000-0002-8149-9186)
- Helen M. Bramlett (ORCID: https://orcid.org/0000-0002-8200-0973)
- Indy Cabeda Diaz
Institutions
- University of Miami (US)
- Brain Physiology Lab (FR)
- Bruce W. Carter VA Medical Center (US)
- Cellular Research (United States) (US)
- Neurological Surgery (US)
- Foster-Miller (United States) (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1161/strokeaha.125.053168
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00