Oral anticoagulants and gastrointestinal bleeding: pharmacovigilance insights from the FDA adverse event reporting system database
DOACs showed a significantly lower risk of GIB than VKAs, though dabigatran exhibited a higher risk of lower GIB compared to other OACs. Different OACs exhibited distinct risk profiles across GIB locations, providing critical insights for optimizing anticoagulation management strategies.
Authors
- Kaili Mao (ORCID: https://orcid.org/0009-0001-1556-4365)
- Yiling He
- Wei Hu (ORCID: https://orcid.org/0000-0002-9107-8027)
- Haiping Wang (ORCID: https://orcid.org/0000-0002-8370-4585)
- Jiale Chen (ORCID: https://orcid.org/0009-0005-3959-6416)
- Jin Xu (ORCID: https://orcid.org/0000-0003-4183-0820)
- Guoquan Chen (ORCID: https://orcid.org/0000-0002-8385-5199)
- Ling Wang
Institutions
- Zhejiang Chinese Medical University (CN)
- Longyan University (CN)
- Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
- Hanalei Watershed Hui (US)
- Jinhua Academy of Agricultural Sciences (CN)
- Quzhou University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1097/js9.0000000000003675
- Citations
- 1
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.31