Direct Binding of Lyn to GPIbβ Transmits 2-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding
Direct binding of Lyn to GPIbβ mediates 2-way GPIb-IX signaling to activate platelets and modulate VWF-GPIb interaction. Lyn-mediated GPIb-IX signaling is critical for platelet adhesion and aggregation induced by VWF and collagen and in arterial thrombosis. Targeting the Lyn-GPIbβ interaction has the potential for treating GPIb-IX-dependent thrombosis.
Authors
- Ni Cheng (ORCID: https://orcid.org/0000-0002-9013-690X)
- Peiwen Cong (ORCID: https://orcid.org/0000-0001-7753-8368)
- Can Wang (ORCID: https://orcid.org/0000-0002-2665-0269)
- Claire Chang (ORCID: https://orcid.org/0000-0002-9258-2540)
- Andrew Mack (ORCID: https://orcid.org/0009-0000-7224-7537)
- Cheng Zhu (ORCID: https://orcid.org/0000-0002-1718-565X)
- Haotian Yang (ORCID: https://orcid.org/0009-0007-3411-5956)
- Yaping Zhang (ORCID: https://orcid.org/0000-0003-0205-8807)
- Amir Hossein Kazemipour Ashkezari (ORCID: https://orcid.org/0000-0002-7441-2927)
- Yanyan Bai (ORCID: https://orcid.org/0000-0002-8365-8451)
- Ying Liang (ORCID: https://orcid.org/0000-0002-2384-1676)
- Xin Huang (ORCID: https://orcid.org/0000-0002-4730-9318)
- Xiaoping Du (ORCID: https://orcid.org/0000-0001-9842-8192)
Institutions
- Georgia Institute of Technology (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1161/circresaha.124.325616
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00