A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis
Our findings elucidate a previously unrecognised A20-KEAP1-NRF2 axis that orchestrates hepatocyte ferroptosis in AIH. Targeting A20 may provide a promising therapeutic strategy for AIH.
Authors
- Wei Yan (ORCID: https://orcid.org/0000-0003-0228-7626)
- Zhuoying Lin (ORCID: https://orcid.org/0009-0009-6222-437X)
- Dean Tian (ORCID: https://orcid.org/0000-0002-1407-6351)
- Mei Liu (ORCID: https://orcid.org/0000-0002-7073-6174)
- Jiaxin Xu (ORCID: https://orcid.org/0000-0002-6797-1413)
- Zhenghao Ye
- Wanneng Li
- Lei Yu (ORCID: https://orcid.org/0000-0003-1093-9188)
- Han Wang (ORCID: https://orcid.org/0009-0007-4486-0693)
- Shuhui Wang (ORCID: https://orcid.org/0000-0003-4546-5664)
- Lijia Wang (ORCID: https://orcid.org/0000-0003-4805-1731)
- Ping Han (ORCID: https://orcid.org/0000-0003-0758-6668)
- Fang Xiao (ORCID: https://orcid.org/0000-0002-7153-454X)
- Meiping Yu (ORCID: https://orcid.org/0000-0002-0351-6964)
- Yan Xu (ORCID: https://orcid.org/0000-0002-9596-2979)
- Yu Chen (ORCID: https://orcid.org/0000-0003-1933-8290)
Institutions
- Shangrao Normal University (CN)
- Christian-Albrechts-Universität zu Kiel (DE)
- Medizinische Hochschule Hannover (DE)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1136/gutjnl-2025-336363
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04