Acute inflammation amplifies the diabetogenic effect of excess adiposity: Evidence from a real‐life, prospective cohort
Acute inflammation significantly elevates diabetes risk in overweight/obese individuals but not in those with normal weight, highlighting the synergistic role of adiposity and immune activation in diabetes pathogenesis and the importance of weight control in prevention strategies.
Authors
- Baoyu Feng (ORCID: https://orcid.org/0000-0003-1718-9025)
- Kuangyi Wu (ORCID: https://orcid.org/0009-0003-9482-216X)
- Yulong Lan (ORCID: https://orcid.org/0000-0002-6143-9709)
- Youren Chen (ORCID: https://orcid.org/0000-0003-4401-3279)
- Huancong Zheng (ORCID: https://orcid.org/0009-0004-2034-4078)
- Lois Balmer (ORCID: https://orcid.org/0000-0001-5618-0555)
- Xiong Ding (ORCID: https://orcid.org/0000-0002-0947-3627)
- Lingyu Xu (ORCID: https://orcid.org/0000-0001-6145-8371)
- Wei Qiang Wang (ORCID: https://orcid.org/0000-0002-1430-1360)
- Xingang Li (ORCID: https://orcid.org/0000-0003-0252-154X)
- Dan Wu (ORCID: https://orcid.org/0000-0002-9367-6557)
Institutions
- Edith Cowan University (AU)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shantou University (CN)
- Wuhan University (CN)
- Kailuan General Hospital (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1111/dom.70274
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00