Comparative Study between Nanofat Graft and Conventional Dressings in Second and Third Degree Acute Burn Patients

Background: A traumatic injury to the skin or other organic tissue that is predominantly brought on by heat or other sudden exposures is called a burn. In order to better manage acute third-degree burns, this study aimed to determine the effectiveness of using nanofat grafts in burn care as well as the possible safety and effectiveness of using both standard dressings and nanofat grafts in combination for treating acute burns. Methods: This randomized controlled clinical trial included 28 Patients with 3rd degree acute burn who were admitted at Department of Plastic Surgery, Faculty of Medicine, Zagazig University. Patients were randomised (ratio 1:1), 14 subjects in each group: Group A underwent Nanofat graft and group B were subjected to conventional dressings. Results: Scar texture was significantly different between both groups with higher prevalence of smooth texture in group A compared to group B (P=0.008). Contractures were significantly lower in group A compared to group B (P<0.001). Wound healing was significantly higher in in group A compared to group B (P<0.001), whereas the need for skin grafts and re-admission were significantly lower in in group A compared to group B (P=0.002, 0.002). Conclusions: Another promising treatment option for unfortunate burn victims is nano fat therapy, which has been shown to improve scar texture and contracture by a statistically significant amount. It also has a higher rate of wound healing and requires fewer skin grafts.