The Effect of Isoflavones in Iraqi Postmenopausal Women

Background: Isoflavones are plant-derived phytoestrogens that have garnered interest for their potential to alleviate menopausal symptoms through mild estrogenic activity. This study aimed to evaluate the clinical effects of isoflavone supplementation in postmenopausal women over a six-month period. Methods: A single-arm, prospective interventional study was conducted involving 60 postmenopausal women, of whom 53 completed the trial. Participants received a daily dose of Active-Meno®, a supplement containing 50 mg of soy isoflavones along with additional micronutrients. Menopausal symptoms were assessed using the validated Menopause Rating Scale (MRS), and serum estradiol and progesterone levels were measured at baseline and after six months. Results: Isoflavone supplementation led to a significant reduction in total MRS scores (from 20.8 ± 4.6 to 13.2 ± 3.9; p < 0.001), with improvements observed across somatic, psychological, and urogenital domains. Estradiol levels increased from 17.4 ± 5.2 pg/mL to 25.6 ± 6.1 pg/mL (p < 0.01), and progesterone levels rose from 0.3 ± 0.1 ng/mL to 0.5 ± 0.2 ng/mL (p < 0.05). No adverse events necessitated discontinuation, and the supplement was well tolerated. Conclusion: These findings support the potential of isoflavones as a safe and effective non-hormonal option for the management of menopausal symptoms.