Resveratrol mitigates Valproic Acid-Induced Autistic Features in mice via up-regulation of Nrf2/HO-1 signaling pathway

Introduction: A neurodevelopmental disease known as autism spectrum disorder (ASD) is linked to stereotypical behavior and poor social skills. Resveratrol (Res) has been shown to possess anti-inflammatory and antioxidant impacts.Objective: to demonstrate the underlying mechanisms and neuroprotective impact of Res in VPA-induced ASDMaterial & methods: Thirty male Swiss mice were split into three : control, VPA, and VPA+Res. Following neurobehavioral testing, the rats were sacrificed, and the cerebellar gene expression of Nrf2 and HO-1 was evaluated together with the measurements of MDA, SOD, TNF-α, IL-6, IL-10 and serotonin. GFAP and Caspase-3 cerebellar immunoreactions were performed. Results: While the VPA group's time of central crossing in OFT, percentage of alternation in the T maze test, Cerebellar SOD, Cerebellar IL-10, and Cerebellar gene expression of Nrf2 and HO-1 were dramatically lower than those of the control, the VPA 's number of crossing slots in OFT, rearing frequency in OFT, Cerebellar MDA, Cerebellar TNF-α, and Cerebellar IL-6 were all dramatically higher than those of the control group with impairments in social interaction. Res substantially reduced VPA-induced ASD.Conclusion: In addition to enhancing gliosis and up-regulating the Nrf2/HO-1 signaling pathway, Res also reduced VPA-induced ASD through anti-oxidant, anti-inflammatory and antiapoptotic pathways.