HEPCIDIN AS A PREDICTIVE MARKER IN HEPATIC AND DIABETIC DISORDERS

In the absence of additional risk factors that contribute to metabolic syndrome, such as hypertriglyceridemia and obesity, type-2 diabetes mellitus may be a risk factor for the development and progression of liver disease. A key component of metabolism is the liver. As a result, it is extremely vulnerable to toxicity caused by chemicals. The present work aimed at studying the effects of T2DM and ethanol induced liver disorders on hepcidin with iron status and some hematological parameters. Fifty adult male albino rats alienated evenly into equal five groups. Group I: normal control group (C), Group II: control iron (CI), Group III: diabetic iron (DI), Group IV: hepatic iron (HI) and Group V: hepatic diabetic iron (HDI). The obtained results showed that the hematological profile was significantly reduced (P<0.05) by T2DM induction and chronic ethanol treatment, while levels of HbA1C, aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TB), hypo-albuminemia, and fasting blood glucose (FBG) were elevated. Moreover, significant changes in serum hepcidin and serum iron profile (iron, ferritin, total iron binding capacity and transferrin saturation %) were recorded in this study. It could be concluded that ethanol administration and T2DM persuade revocable alterations in hematology and biochemical markers.