SIRT1(rs7069102) Gene Polymorphism in Chronic Obstructive Pulmonary Disease in Egyptian Patients

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent condition characterized by shortness of breath, coughing, and sputum production. In Egypt, the prevalence is around 7.5%, with key risk factors including smoking and pollution. Objective: This study examined the association between the SIRT1 SNP (rs7069102) and CRP levels, and the roles of IL-26 and IL-10 in Egyptian COPD patients. Methodology: A case-control study involved 100 COPD patients and 100 healthy controls. Participants underwent assessments for BMI and spirometry, along with blood sampling for SIRT1 genotyping and measurement of IL-10 and IL-26. Results: The results highlighted reduced pulmonary function, elevated IL-26 levels, and lower IL-10 levels in COPD patients. Notably, serum IL-26 and IL-10 both demonstrated 100% sensitivity and specificity for diagnosing COPD at defined cutoffs. Conclusion: The SIRT1 (rs7069102) SNP may be a novel link to COPD, with patients showing a higher frequency of certain genotypes and altered cytokine levels.