Recent Advances in Quinolone based Derivatives as Potential Anticancer Agents

As a result for the great annual increase in patients suffering from cancer. There is urgent need for designing new small molecule chemotherapeutic agents that selectively target cancer cells without or with minimal effect on normal cells.Quinolone derivatives are fused heterocyclic ring systems that are explored for their diverse biological activities with the potential for treatment of many diseases such as antimalarial, antibacterial, antifungal, antiviral, antibacterial, antioxidant and their role as broad spectrum anticancer agents. The present mini review is to represent the most recent pharmaceutical aspects and synthetic approaches of different substituted quinolones as anticancer agents reported to date.Also, Displaying the recent quinolone derivatives recommended or present in preclinical and clinical studies. In addition to showing the importance of the structure activity relationship in designing new lead compounds with potential antitumor activity. Moreover, exploring the effect of different hybridizations with quinolone analogues for designing potent anticancer agents.