Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma
ROTA uncovers a wide spectrum of RNFL bundle defects spanning the entire glaucoma continuum. It also provides visualisation of the preserved RNFL bundles in advanced glaucoma. Papillomacular and papillofoveal RNFL bundle defects are present in a considerable proportion of eyes with early, moderate and advanced glaucoma, and, when detected, they significantly increase the likelihood of abnormality in the corresponding central 24-2 test locations.
Authors
- Alireza Kamalipour (ORCID: https://orcid.org/0000-0003-2916-9187)
- Sasan Moghimi (ORCID: https://orcid.org/0000-0002-9375-4711)
- Michael Saheb Kashaf (ORCID: https://orcid.org/0000-0001-5876-7421)
- Mohsen Adelpour (ORCID: https://orcid.org/0000-0002-1439-3023)
- Pooya Khosravi (ORCID: https://orcid.org/0000-0002-3631-4760)
- Robert Neal Weinreb (ORCID: https://orcid.org/0000-0001-9553-3202)
- Andrew Camp (ORCID: https://orcid.org/0000-0001-5954-5257)
- Natchada Tansuebchueasai (ORCID: https://orcid.org/0000-0003-4776-9610)
- Linda M. Zangwill (ORCID: https://orcid.org/0000-0002-1143-5224)
- Takashi Nishida (ORCID: https://orcid.org/0000-0002-8312-6623)
- Gopikasree Gunasegaran (ORCID: https://orcid.org/0009-0008-6717-9363)
- Christopher Kai-Shun Leung
- Alexander K. N. Lam
- Cristiana Vasile
Institutions
- Prince of Songkla University (TH)
- University of California San Diego (US)
- Smith-Kettlewell Eye Research Institute (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1136/bjo-2024-326968
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.41