High lipoprotein(a) attenuates the mortality benefit of elevated high-density lipoprotein cholesterol with sex-specific variation: a retrospective cohort study
Elevated Lp(a) enhances mortality risk despite elevated HDL-C levels, with sex-specific differences: women retain mortality benefits from high HDL-C despite elevated Lp(a), whereas men with concurrent elevations in HDL-C and Lp(a) experienced mortality risks comparable to those with low HDL-C. Findings underscore sex-specific CV risk stratification incorporating HDL-C and Lp(a), challenging the HDL-C universal protective role.
Authors
- Hesham Sheashaa
- Milagros Pereyra (ORCID: https://orcid.org/0000-0003-4695-8436)
- Ahmed K. Mahmoud
- Ramzi Ibrahim (ORCID: https://orcid.org/0009-0003-1690-3845)
- Isabel G. Scalia (ORCID: https://orcid.org/0000-0002-6459-9767)
- Mahmoud Hassan Abdelnabi (ORCID: https://orcid.org/0000-0001-8016-9049)
- Kamal Awad (ORCID: https://orcid.org/0000-0001-6707-1629)
- Juan Farina (ORCID: https://orcid.org/0000-0002-5824-8485)
- Nadera N. Bismee
- Fatmaelzahraa E. Abdelfattah (ORCID: https://orcid.org/0009-0008-0758-1086)
- Nima Baba Ali
- Chadi Ayoub (ORCID: https://orcid.org/0000-0001-5877-7478)
- Mohammed Tiseer Abbas
- Steven J. Lester
- Sogol Attaripour Esfahani
- Omar Ibrahim (ORCID: https://orcid.org/0009-0003-2530-7850)
- Reza Arsanjani
Institutions
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Coronary Artery Disease
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1097/mca.0000000000001589
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00