Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells
Multifunctional Zr-TPY-Fe/cy/Au nanosheets are developed for self-boosted chemodynamic therapy (CDT) by combining glucose oxidase (GOx)- and peroxidase (POD)-like activities. Au NPs generate H<sub>2</sub>O<sub>2</sub> from glucose, which feeds terpyridine-Fe sites to produce ˙OH, achieving ROS-mediated cytotoxicity in TNBC cells.
Authors
- Wenhui Yang (ORCID: https://orcid.org/0009-0007-1994-7033)
- Xuefu Hu (ORCID: https://orcid.org/0000-0001-8859-0241)
- Gen Li (ORCID: https://orcid.org/0000-0003-0087-7796)
- Xiaoli Chen (ORCID: https://orcid.org/0000-0001-7734-9567)
- Nan Yu (ORCID: https://orcid.org/0000-0002-2946-6790)
- Xiuli Zhang
Institutions
- Bengbu Medical College (CN)
- Anhui Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04635a
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00