Prospective phase II clinical trial of molecular glioblastoma (historical grade 2 and 3 IDH wildtype gliomas) preliminary novel exploratory analyses
Our results demonstrate underlying heterogeneity within the molGBM population, pointing to future hypothesis-generating risk stratification strategies. We also demonstrate the feasibility of CTV reduction with therapy intensification to set a practice standard for RT management of non-enhancing molGBM.
Authors
- Chirag B. Patel (ORCID: https://orcid.org/0000-0003-0787-0634)
- Maria A. Gubbiotti (ORCID: https://orcid.org/0000-0003-2246-7958)
- Arnold C. Paulino (ORCID: https://orcid.org/0000-0002-0269-3045)
- Ashley Aaroe (ORCID: https://orcid.org/0000-0002-9494-6985)
- Carlos Kamiya-Matsuoka
- Ceylan Altıntaş Taşlıçay (ORCID: https://orcid.org/0000-0003-4459-4114)
- Benjamin T. Whitfield (ORCID: https://orcid.org/0000-0002-2624-8464)
- Susan L. McGovern (ORCID: https://orcid.org/0000-0002-5286-0649)
- Maria Gule-Monroe (ORCID: https://orcid.org/0000-0002-4418-3705)
- Vinay K. Puduvalli (ORCID: https://orcid.org/0000-0001-8396-9500)
- David R. Grosshans
- Moshe Maor (ORCID: https://orcid.org/0000-0003-0411-2977)
- Caroline Chung
- Cheng‐Han Yang (ORCID: https://orcid.org/0000-0001-7574-0458)
- Ruitao Lin (ORCID: https://orcid.org/0000-0003-2244-131X)
- Amol J. Ghia (ORCID: https://orcid.org/0000-0002-6965-4577)
- Monica Loghin
- Nazanin Majd (ORCID: https://orcid.org/0000-0001-6451-544X)
- Leomar Y. Ballester (ORCID: https://orcid.org/0000-0002-6854-6830)
- Martin C. Tom (ORCID: https://orcid.org/0000-0002-2757-8641)
- Thomas Hendrix Beckham (ORCID: https://orcid.org/0000-0001-6189-6996)
- Subha Perni (ORCID: https://orcid.org/0000-0003-2851-4903)
- Jeffrey S. Wefel (ORCID: https://orcid.org/0000-0002-3817-2479)
- Brian De (ORCID: https://orcid.org/0000-0003-3468-3359)
- D.N. Yeboa (ORCID: https://orcid.org/0000-0002-2901-7477)
- Wen Jiang (ORCID: https://orcid.org/0000-0001-9154-633X)
- Chinenye Lynette Ejezie
- Chenyang Wang (ORCID: https://orcid.org/0000-0001-6798-0857)
- Jing Li (ORCID: https://orcid.org/0000-0002-1361-4525)
- Anuj Patel (ORCID: https://orcid.org/0000-0002-8545-345X)
- R. C. Harrison (ORCID: https://orcid.org/0000-0001-8355-2406)
- Jason T. Huse (ORCID: https://orcid.org/0000-0003-4514-0640)
- Mary Frances McAleer
- Barbara O’Brien
- Todd A. Swanson
- Shiao-Pei Weathers
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of British Columbia (CA)
- Yale University (US)
- Towson University (US)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1007/s11060-025-05269-6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Robert and Janice McNair Foundation
- Pfizer
- National Institutes of Health
- EMD Serono
- University of Texas MD Anderson Cancer Center
- National Cancer Institute