Evaluation of glycine treatment for reducing alcohol craving and self‐administration in individuals with alcohol use disorder: A human laboratory trial

Glycine treatment does not reduce craving or laboratory alcohol consumption in individuals with AUD per se, but results are equivocal as the association between alcohol-induced craving or "wanting more" and the ensuing self-administration of alcohol was abolished in the glycine-treated group. The inverse association observed between glycine levels at baseline and self-reported recent drinking could be a consequence of alcohol intake or support a protective role for glycine activity in limiting alcohol intake. Further studies are warranted to delineate how GlyR activity is linked to alcohol consumption in humans and to establish whether targeting this system may constitute a new treatment concept for AUD.