Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications
The findings underscore the involvement of mitophagy in the pathobiology of PAH and identify five macrophage-associated biomarkers with strong diagnostic potential. These results may inform future strategies aimed at early detection and targeted therapeutic interventions in PAH.
Authors
- Wenting Gui
- Kai Liu (ORCID: https://orcid.org/0000-0002-3374-3375)
- Xuejuan Ma
- Runwei Ma (ORCID: https://orcid.org/0000-0002-2817-9351)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0003-4603-2908)
- Liming Cheng (ORCID: https://orcid.org/0000-0001-6444-5090)
- Jiaxiang Chen (ORCID: https://orcid.org/0000-0002-4240-2441)
- Jiahui Xie (ORCID: https://orcid.org/0009-0008-9434-9153)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Kunming Children's Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fphys.2025.1673181
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Medical University