Immune-related adverse events are a potent predictor of post-transplant rejection in HCC: a multicentre retrospective cohort study
This study identified irAEs as a potent predictor of allograft rejection in HCC patients receiving pretransplant ICIs, potentially driven by heightened immune activation. The predictive model may help stratify patients at high risk of rejection.
Authors
- Qi Ling (ORCID: https://orcid.org/0000-0002-7377-2381)
- Shugeng Zhang (ORCID: https://orcid.org/0000-0001-9832-9784)
- Feng Gao (ORCID: https://orcid.org/0000-0002-1425-1623)
- Andre Mu (ORCID: https://orcid.org/0000-0002-0853-9743)
- Li Zhao (ORCID: https://orcid.org/0000-0002-6297-528X)
- Tielong Wang (ORCID: https://orcid.org/0000-0001-7547-9819)
- Marcus Eng Hock Ong (ORCID: https://orcid.org/0000-0001-7874-7612)
- Yimou Lin (ORCID: https://orcid.org/0000-0002-0910-1137)
- Hao Li (ORCID: https://orcid.org/0000-0003-2832-4851)
- Ning Wang (ORCID: https://orcid.org/0000-0002-1849-1747)
- Li Zhuang (ORCID: https://orcid.org/0000-0002-2487-463X)
- Zhihao Wang (ORCID: https://orcid.org/0000-0003-1561-4040)
- Shusen Zheng (ORCID: https://orcid.org/0000-0003-1459-8261)
- Zhiyong Guo (ORCID: https://orcid.org/0000-0001-8791-0020)
- Jun Fang (ORCID: https://orcid.org/0000-0002-8613-918X)
- Kang He (ORCID: https://orcid.org/0000-0003-4671-1337)
- Zebin Zhu (ORCID: https://orcid.org/0000-0002-2630-7604)
- Jian-Cheng Wu
- Siyi Zhong
Institutions
- University of Science and Technology of China (CN)
- Sun Yat-sen University (CN)
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Xiamen University (CN)
- Peking University (CN)
- Renji Hospital (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Peking University People's Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Hangzhou Red Cross Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1136/gutjnl-2025-336719
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- Fundamental Research Funds for the Central Universities