Integrated Transcriptomic and Metabolomic Analysis Revealed That Tryptophan Metabolism–Related Metabolites Are Biomarkers of Trastuzumab Resistance
Our explored the changes induced by trastuzumab resistance in terms of metabolite abundance and gene transcription levels associated with tryptophan metabolism. Furthermore, this work provided new insights into novel diagnostic biomarkers and prediction models of trastuzumab resistance in HER2-positive breast cancer patients.
Authors
- Juan Wei (ORCID: https://orcid.org/0000-0003-4345-307X)
- Xinxin Si (ORCID: https://orcid.org/0000-0003-0393-4223)
- Z Wang (ORCID: https://orcid.org/0009-0005-2399-8891)
- HengAn Wu (ORCID: https://orcid.org/0000-0003-0288-1617)
- Changfei Mao
- Yiwei Cao
- Bangbang Wei
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Cancer Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1002/jcla.70124
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing University of Chinese Medicine
- Nanjing University