Single‐Dose, Long‐Acting Injectable Buprenorphine for Opioid Withdrawal Treatment

Given the stability of OAT patients on LAIB, it was inferred that some patients may do well in opioid withdrawal management using LAIB, should other conventional treatments not succeed. This was based on previous pharmacokinetic data and modelling by others which would allow for a slow, in vivo wean of the drug rather than discrete, daily dose reductions. For patients, this could reduce potential withdrawal symptoms and shorten admission lengths in hospital withdrawal management wards. Further research is needed to verify these results, but these preliminary data are encouraging.

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Publication Details

Journal
Drug and Alcohol Review
Published
2025-11-04
DOI
https://doi.org/10.1111/dar.70070
Primary Topic
Opioid Use Disorder Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Single‐Dose, Long‐Acting Injectable Buprenorphine for Opioid Withdrawal Treatment

Prasun K. Datta, Justin F. Fraser, Jeffrey S. Kruk, Karen A. Fisher
Drug and Alcohol Review
Opioid Use Disorder Treatment
article

Single‐Dose, Long‐Acting Injectable Buprenorphine for Opioid Withdrawal Treatment

Prasun K. Datta, Justin F. Fraser, Jeffrey S. Kruk, Karen A. Fisher
article en

Abstract

Given the stability of OAT patients on LAIB, it was inferred that some patients may do well in opioid withdrawal management using LAIB, should other conventional treatments not succeed. This was based on previous pharmacokinetic data and modelling by others which would allow for a slow, in vivo wean of the drug rather than discrete, daily dose reductions. For patients, this could reduce potential withdrawal symptoms and shorten admission lengths in hospital withdrawal management wards. Further research is needed to verify these results, but these preliminary data are encouraging.

Drug and Alcohol ReviewVol. 45(1)
Nepean Hospital (AU)
Openalex Percentile: Top 57%
Opioid Use Disorder Treatment
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Single‐Dose, Long‐Acting Injectable Buprenorphine for Opioid Withdrawal Treatment — Prasun K. Datta, Justin F. Fraser, et al. · Drug and Alcohol Review (2025) | TGRS Research Map | TGRS