Polystyrene nanoparticles reduce the Cryptococcus neoformans virulence via induction of mitochondrial dysfunction
These results suggest that PS-NPs inhibit the formation of the <i>C. neoformans</i> capsule, potentially by inducing mitochondrial dysfunction. Furthermore, the findings highlight the broader implications of PS-NPs on fungal virulence and the dynamics of host-pathogen interactions, underscoring their significance in advancing our understanding of these complex relationships.
Authors
- Xinyuan Zhao (ORCID: https://orcid.org/0000-0002-7317-8016)
- Peng Xue (ORCID: https://orcid.org/0000-0003-2755-7987)
- Bin Xu (ORCID: https://orcid.org/0000-0002-9251-6930)
- Dongnan Zheng
- Yifan Zhou (ORCID: https://orcid.org/0000-0003-0980-7129)
- Yuanyuan Ma (ORCID: https://orcid.org/0009-0008-3249-8356)
- Fengxu Wang (ORCID: https://orcid.org/0000-0002-1196-6033)
- Wenxia Bu
Institutions
- Nantong University (CN)
- Jiangxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fcimb.2025.1708192
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China