Influence of diabetes on the efficacy of DL-3-n-butylphthalide in post-stroke cognitive impairment: a 12-month prospective cohort study
In non-diabetic patients with subacute IS, NBP exerts more pronounced protective effects on overall cognition and language. In contrast, in diabetic patients, only a slight improvement in orientation is observed. Clinically, it is essential to prioritize optimization of diabetes management based on blood glucose control status before considering the addition of NBP. Further validation of these exploratory findings is warranted through larger-scale randomized trials.
Authors
- Juan Hao (ORCID: https://orcid.org/0009-0009-1770-5617)
- Xianjia Ning (ORCID: https://orcid.org/0000-0002-1398-3515)
- Chenxi Fan (ORCID: https://orcid.org/0000-0002-8653-4999)
- Lifeng Wang (ORCID: https://orcid.org/0000-0001-5095-6842)
- Jinghua Wang (ORCID: https://orcid.org/0000-0003-2619-0570)
- Jingjing Song (ORCID: https://orcid.org/0000-0002-5682-9550)
- Yan Li (ORCID: https://orcid.org/0000-0001-9078-5101)
- Yuting Lu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin People's Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fnagi.2025.1649248
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00