Case Report: HGF and NF1 mutations as putative bypass mechanisms of MET inhibitor resistance in hepatocellular carcinoma: a case study
Our findings suggest that acquired resistance to MET inhibitors in MET-amplified HCC may involve clonal evolution and activation of compensatory signaling pathways. These insights highlight the need for dynamic molecular surveillance and the development of strategies targeting multiple pathways to overcome resistance and improve patient outcomes.
Authors
- Sijie Luo (ORCID: https://orcid.org/0000-0001-9587-4402)
- Qiyong Li (ORCID: https://orcid.org/0000-0001-7203-3707)
- Yangjun Gu (ORCID: https://orcid.org/0000-0001-7666-8697)
- Zhitao Chen (ORCID: https://orcid.org/0000-0002-7054-6549)
Institutions
- Zhejiang Shuren University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fphar.2025.1659463
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Shuren University