Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats
Findings suggest that changes in physiological parameters describing patterns of chronic inflammation are associated with measurable cognitive changes in aging cats, in the absence of overt clinical disease, which is consistent with the concept of inflammaging. Routine monitoring of standard bloodwork and BCS may offer an accessible means of tracking chronic subclinical inflammation and predicting cognitive aging in senior feline patients. These results highlight the importance of proactive cognitive screening and client education to preserve welfare and the human-animal bond in aging cats.
Authors
- P. Scarpa (ORCID: https://orcid.org/0000-0002-2316-1929)
- Federica Pirrone (ORCID: https://orcid.org/0000-0001-8641-3858)
- M. Albertini (ORCID: https://orcid.org/0000-0002-6969-7809)
- Darko Stefanovski (ORCID: https://orcid.org/0000-0002-4654-0569)
- Patrizia Piotti (ORCID: https://orcid.org/0000-0001-7761-8712)
- Carlo Siracusa (ORCID: https://orcid.org/0000-0002-9154-2950)
- Lena Provoost
- Joel Filipe (ORCID: https://orcid.org/0000-0001-8849-2051)
- Holly Memoli
- Irit Grader
Institutions
- University of Milan (IT)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fnagi.2025.1703764
- Primary Topic
- Human-Animal Interaction Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania