TGF-β-driven NK Cells plasticity in hepatocellular carcinoma
our findings suggest that while non-canonical TGF-β signaling drives phenotypic reprogramming and contributes to NK cell dysfunction, canonical SMAD-dependent signaling remains a key therapeutic target for functional restoration. These results highlight the dual role of TGF-β in immune modulation and suggest that targeted pathway inhibition could enhance innate anti-tumor responses, opening new avenues for combination therapies in HCC.
Authors
- Valentina Reverberi (ORCID: https://orcid.org/0000-0001-5703-1957)
- Anna Montali (ORCID: https://orcid.org/0000-0002-1134-7435)
- Diletta Laccabue (ORCID: https://orcid.org/0000-0002-8612-8042)
- Amalia Penna (ORCID: https://orcid.org/0000-0001-9663-1250)
- Paola Fisicaro (ORCID: https://orcid.org/0000-0003-3720-9214)
- Carolina Boni (ORCID: https://orcid.org/0000-0002-7630-5180)
- Andrea Olivani (ORCID: https://orcid.org/0000-0002-6199-1819)
- Raffaele Dalla Valle (ORCID: https://orcid.org/0000-0003-4847-6924)
- Gabriele Missale (ORCID: https://orcid.org/0000-0001-6691-8701)
- Andrea Vecchi (ORCID: https://orcid.org/0000-0001-8595-0651)
- Marzia Rossi (ORCID: https://orcid.org/0000-0003-4336-8502)
- Sara Doselli (ORCID: https://orcid.org/0009-0000-7533-0862)
- Benedetta Farina (ORCID: https://orcid.org/0000-0002-4696-7554)
- Alessio Pelagatti (ORCID: https://orcid.org/0009-0008-3884-2760)
- Giorgio Economopoulos
- Francesca Ferraglia
Institutions
- University of Parma (IT)
- Ospedale di Parma (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1651129
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Fondazione Cariparma
- European Commission
- Università degli Studi di Parma