Machine learning-based tumor associated macrophages polarity signature predicts prognosis and treatment response in hepatocellular carcinoma
We developed and validated a robust TAM polarity-related signature that effectively stratifies HCC patients by prognosis. TPS provides insights into tumor immunity, metabolism, and drug response, and may serve as a valuable tool for precision medicine in HCC.
Authors
- Shichun Lu (ORCID: https://orcid.org/0000-0003-3278-0534)
- Fangzhou Wang (ORCID: https://orcid.org/0000-0002-9640-5285)
- Yamin Zheng
- Quan Zhang (ORCID: https://orcid.org/0009-0003-9518-5174)
Institutions
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- Beijing Xuanwu Traditional Chinese Medicine Hospital (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1663519
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00