Synergistic benefits of melatonin and therapeutic exercise as a unified strategy for managing stroke and doxorubicin-induced cardiotoxicity

MT + Ex reduced brain infarct volume and neurological deficits, enhanced neuronal growth, and provided superior cardioprotection, preventing heart weight loss and histopathological damage. This study is the first to show synergistic protective action of MT and Ex against stroke and DIC, contributing key insights into an interplay between neurological and cardiovascular health and addressing multifaceted challenges posed by stroke, and anticancer interventions.