Resolution of chronic idiopathic urticaria with setmelanotide in a patient with Bardet-Biedl Syndrome: A case report
Setmelanotide produced durable remission of refractory CIU in a patient with BBS, suggesting MC4R agonism may exert immunomodulatory effects beyond weight regulation. This finding underscores the broader potential of precision therapies for rare obesity syndromes to reveal new mechanisms of inflammation control.
Authors
- Jennifer D. Black (ORCID: https://orcid.org/0000-0001-8813-6604)
- Kate Haggerty
- Ruth Abeles (ORCID: https://orcid.org/0009-0004-7596-4813)
Institutions
- University of California San Diego (US)
- Carolina Women's Research and Wellness Center (US)
- Washington Center for Weight Management and Research (US)
Publication Details
- Journal
- Obesity Pillars
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.obpill.2025.100221
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00