Genetically Estimated Ancestry and the Risk of Pre-Eclampsia
SRE imperfectly represents genetic ancestry in multiethnic populations. West AFR ancestry independently associates with the PE risk, supporting biological relevance of ancestry-based stratification. However, genetic ancestry did not improve the gold-standard clinical prediction model performance. Large genomic studies in multiethnic cohorts are needed to delineate the genetic architecture of PE.
Authors
- Peter Dixon (ORCID: https://orcid.org/0000-0002-0197-2632)
- Pirro G. Hysi (ORCID: https://orcid.org/0000-0001-5752-2510)
- Frances Conti‐Ramsden (ORCID: https://orcid.org/0000-0001-7081-6839)
- Lucy C. Chappell (ORCID: https://orcid.org/0000-0001-6219-3379)
- Catherine Williamson (ORCID: https://orcid.org/0000-0002-6226-7611)
- Argyro Syngelaki
- Antonio de Marvao (ORCID: https://orcid.org/0000-0001-9095-5887)
- Kypros H. Nicolaides (ORCID: https://orcid.org/0000-0003-3515-7684)
- Alan Wright (ORCID: https://orcid.org/0000-0002-3448-6446)
- Maria Tsoukaki
Institutions
- King's College London (GB)
- British Heart Foundation (GB)
- Harris Birthright Research Centre for Fetal Medicine (GB)
- University College London (GB)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102283
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00