CLINICAL SPECTRUM OF AN EGYPTIAN COHORT OF CHILDREN WITH MYELODYSPLASTIC SYNDROME

NRAS alone 4.7% at diagnosis) with UBA1 mutation arising second (NRAS+UBA1: 27.3%).The NRAS+UBA1-mutant clone demonstrated myeloid bias compared to NRAS-only and wildtype cells.Purified CD34+ cells showed enrichment of both UBA1 and NRAS mutations, suggesting preferential expansion within hematopoietic stem/progenitor cells.Conclusions

Authors

Sara Makkeyah (ORCID: https://orcid.org/0000-0002-3649-5725)
Nihal Hussien Aly (ORCID: https://orcid.org/0000-0002-8042-8546)
Menna Allah Zakaria Abou Elwafa
Marwa Waheed Tolba (ORCID: https://orcid.org/0000-0002-1723-9785)
E. Ahmed

Institutions

Ain Shams University (EG)
Ain Shams University Hospital (EG)

Publication Details

Journal: EJC Paediatric Oncology
Published: 2025-11-05
DOI: https://doi.org/10.1016/j.ejcped.2025.100405
Primary Topic: Cardiomyopathy and Myosin Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

CLINICAL SPECTRUM OF AN EGYPTIAN COHORT OF CHILDREN WITH MYELODYSPLASTIC SYNDROME

Sara Makkeyah, Nihal Hussien Aly, Menna Allah Zakaria Abou Elwafa, Marwa Waheed Tolba et al.

Nov 5, 2025

EJC Paediatric Oncology

Cardiomyopathy and Myosin Studies

article

CLINICAL SPECTRUM OF AN EGYPTIAN COHORT OF CHILDREN WITH MYELODYSPLASTIC SYNDROME

Sara Makkeyah, Nihal Hussien Aly, Menna Allah Zakaria Abou Elwafa, Marwa Waheed Tolba, E. Ahmed

November 5, 2025article en

Abstract

NRAS alone 4.7% at diagnosis) with UBA1 mutation arising second (NRAS+UBA1: 27.3%).The NRAS+UBA1-mutant clone demonstrated myeloid bias compared to NRAS-only and wildtype cells.Purified CD34+ cells showed enrichment of both UBA1 and NRAS mutations, suggesting preferential expansion within hematopoietic stem/progenitor cells.Conclusions

EJC Paediatric OncologyVol. 6

Ain Shams University (EG), Ain Shams University Hospital (EG)

Openalex Percentile: Top 50%

Cardiomyopathy and Myosin Studies

DOI Open Access PDF OpenAlex

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