MYELODYSPLASTIC SYNDROME IN CHILDHOOD: THE HACETTEPE COHORT
NRAS alone 4.7% at diagnosis) with UBA1 mutation arising second (NRAS+UBA1: 27.3%).The NRAS+UBA1-mutant clone demonstrated myeloid bias compared to NRAS-only and wildtype cells.Purified CD34+ cells showed enrichment of both UBA1 and NRAS mutations, suggesting preferential expansion within hematopoietic stem/progenitor cells.Conclusions
Authors
- Şule Ünal (ORCID: https://orcid.org/0000-0002-3842-8788)
- Selin Aytaç (ORCID: https://orcid.org/0000-0003-2192-298X)
- Barış Kuşkonmaz (ORCID: https://orcid.org/0000-0002-1207-4205)
- Tekin Aksu (ORCID: https://orcid.org/0000-0003-4968-109X)
- Fatma Uğur (ORCID: https://orcid.org/0000-0002-0059-5636)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.ejcped.2025.100407
- Primary Topic
- Myofascial pain diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00