REFRACTORY CYTOPENIA OF CHILDHOOD WITH NORMAL KARYOTYPE: LONG-TERM RESULTS OF AN OBSERVATIONAL APPROACH
Background: Refractory Cytopenia of Childhood (RCC) is a well-recognized form of bone marrow failure, characterized by persistent cytopenia, dysplastic changes, and a distinct histopathologic pattern in the bone marrow. While hematopoietic stem cell transplantation (HSCT) is typically indicated for patients with severe cytopenia or an abnormal karyotype, a subset of RCC patients may be suitable for an observational approach.
Authors
- Reinhard Kalb (ORCID: https://orcid.org/0000-0003-3906-6907)
- Axel Karow (ORCID: https://orcid.org/0000-0003-3963-7271)
- Miriam Erlacher (ORCID: https://orcid.org/0000-0002-7261-1447)
- Marcin W. Włodarski (ORCID: https://orcid.org/0000-0001-6638-9643)
- Yvonne Lisa Behrens (ORCID: https://orcid.org/0000-0002-2390-0541)
- Stephan Schwarz‐Furlan
- Brigitte Strahm (ORCID: https://orcid.org/0000-0002-6086-130X)
- Senthilkumar Ramamoorthy (ORCID: https://orcid.org/0000-0003-3468-4247)
- Dirk Lebrecht (ORCID: https://orcid.org/0000-0002-4483-2920)
- Peter Noellke (ORCID: https://orcid.org/0000-0002-0281-4732)
- Shinsuke Hirabayashi (ORCID: https://orcid.org/0000-0001-7961-0968)
- Ayami Yoshimi (ORCID: https://orcid.org/0000-0003-1593-9507)
- Fabian Beier (ORCID: https://orcid.org/0000-0002-3718-8217)
- Gudrun Göhring (ORCID: https://orcid.org/0000-0002-0863-8645)
- Natalia Rotari
- Irith Baumann (ORCID: https://orcid.org/0000-0003-0026-7859)
- Beatrice Drexler (ORCID: https://orcid.org/0000-0002-7046-0825)
- Martina Rudelius (ORCID: https://orcid.org/0000-0001-6928-9955)
- Charlotte Niemeyer
Institutions
- St. Jude Children's Research Hospital (US)
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Sapporo University (JP)
- University of Würzburg (DE)
- University Medical Center Freiburg (DE)
- University Hospital of Basel (CH)
- Medizinische Hochschule Hannover (DE)
- Sensor-Technik Wiedemann (Germany) (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Hospital Ulm (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.ejcped.2025.100330
- Primary Topic
- Blood disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00