HEPATITIS-ASSOCIATED VS IDIOPATHIC PAEDIATRIC APLASTIC ANAEMIA: CLONAL ARCHITECTURE AND DISEASE TRAJECTORY
Background and Aims: Between 2004 and 2025, 72 paediatric patients were treated for aplastic anaemia (AA) in the Czech Republic, comprising 43 idiopathic and 29 hepatitis-associated (HA-AA). Among HA-AA patients, 21 were classified as AA, and 8 as refractory cytopenia of childhood (RCC). 20 of 29 HA-AA patients were male. Of 43 idiopathic AA patients, 12 received upfront HSCT and 31 IST (13 later transplanted); in HA-AA, 7 received upfront HSCT and 22 IST (9 later transplanted). Two patients required liver transplantation.
Authors
- Tomáš Kuhn (ORCID: https://orcid.org/0000-0003-3800-670X)
- Jan Trka (ORCID: https://orcid.org/0000-0002-9527-8608)
- Ondřej Hrušák (ORCID: https://orcid.org/0000-0002-7611-1335)
- Ondřej Zapletal (ORCID: https://orcid.org/0000-0003-3009-7491)
- Jan Starý (ORCID: https://orcid.org/0000-0002-6818-7743)
- Michaela Reiterová
- Andrea Rennerová (ORCID: https://orcid.org/0000-0002-0510-1543)
- Eva Froňková
- Pavel Timr
- Veronika Kanderová (ORCID: https://orcid.org/0000-0001-8513-1066)
- Martina Vašková (ORCID: https://orcid.org/0000-0001-7039-7515)
- Lucie Šrámková (ORCID: https://orcid.org/0000-0002-1035-422X)
- Michael Svatoň (ORCID: https://orcid.org/0000-0003-2966-3687)
- Tomáš Votava
- Vít Campr
- Iveta Janotová
- Dagmar Pospı́šilová (ORCID: https://orcid.org/0000-0002-1300-7290)
- Daniel Dulla
Institutions
- Charles University (CZ)
- University Hospital Ostrava (CZ)
- University Hospital in Motol (CZ)
- University Hospital Brno (CZ)
- University Hospital Olomouc (CZ)
- University Hospital Plzen (CZ)
- Nemocnice České Budějovice (CZ)
- Medical University of Vienna (AT)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.ejcped.2025.100362
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00