Transcriptomic analysis reveals TME-mediated macrophage IFIT1 upregulation and CX3CR1 suppression drive osteosarcoma progression
Stimulation of the OS TME can change the gene expression of macrophages. Our findings offer a cellular and molecular reference for future investigations of therapeutic targets of OS.
Authors
- Jinmin Zhao (ORCID: https://orcid.org/0000-0002-1047-8820)
- Yuangang Su (ORCID: https://orcid.org/0000-0002-1308-2688)
- Hua He (ORCID: https://orcid.org/0000-0002-7756-1039)
- Jiamin Liang (ORCID: https://orcid.org/0000-0002-5098-7208)
- Keyi Wang (ORCID: https://orcid.org/0000-0002-6520-1562)
- Qian Liu (ORCID: https://orcid.org/0000-0002-1937-0568)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fonc.2025.1686854
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province