Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance
Our findings suggest the involvement of CPA2, GFRA1 and IL12, among other neurology-related proteins, in the early phases of psychosis, which, if confirmed, could become promising biomarkers for diagnosis, psychotic symptom development and psychosis-associated cognitive impairment. However, future studies with larger samples, a longitudinal design, and more extensive proteomic panels are needed to validate these biomarkers and refine their clinical applicability.
Authors
- Martí Llaurador-Coll (ORCID: https://orcid.org/0000-0001-7095-7041)
- Itziar Montalvo (ORCID: https://orcid.org/0000-0002-7320-5109)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Elisabet Vilella (ORCID: https://orcid.org/0000-0002-1887-5919)
- Javier Labad (ORCID: https://orcid.org/0000-0003-2214-1886)
- Vanessa Sánchez‐Gistau (ORCID: https://orcid.org/0000-0002-8635-7144)
- Francesc Estrada
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Institut Pere Mata (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Maresme Health Consortium (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Corporació Sanitària Parc Taulí (ES)
- UK Dementia Research Institute (GB)
- University College London (GB)
- Universitat Rovira i Virgili (ES)
- Indian Institute of Science Bangalore (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.bbih.2025.101134
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00