Effects of moderate-to-vigorous physical activity on the associations between an insulin resistance surrogate and incident cardiovascular disease and all-cause mortality: a UK Biobank cohort study

Our findings highlight the importance of engaging in guideline-recommended MVPA (150-299 min/week) to reduce all-cause mortality risk, particularly among individuals with moderate IR (TyG-WHtR, 7.01-8.03), who are more likely to benefit. Furthermore, the protective effects of higher levels of MVPA against IR-related risks were consistent with those of guideline-recommended MVPA.